Wound healing potential of tridax procumbens l. in alloxan-induced immune compromised mice

Smita Nair., Savita Dixit and Ganesh N

The therapeutic properties of hydro-methanolic extract of Tridex procumbens (METP) was screened for healing potential of dermal wounds of Alloxan-induced diabetic mice. The preliminary studies used hydro-methanolic plant extract (aerial parts) for evaluating antimicrobial properties against common pathogens. Lowering of fasting blood glucose (FBG) was monitored along with reduction of wound area in excision wound models. Dosing of 5mg/kg body weight and 2mg/kg body weight by topical application for 12 consecutive days showed a dose dependent reduction in elevated blood glucose and significant wound contraction as compared to diabetic control. METP also seemed to have an effect in regulating the body weights of the treated mice. Based on these results, it can be concluded that METP can be useful for immune suppressed wound healing and as skin repair agent in conditions similar to those applied by traditional medicine for hyperglycemia.

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