Synergistic effects of abelmoschusesculentus and vernoniaamygdalina in controlling diabetes mellitus in rat models

Author: 
Vempati Poornodai., Srinivasu K., Manju Thomas and Vulli Venkata Rao

Background: Diabetes mellitus is one of the main causes of serious maladies in the 21st century. Diabetes mellitus is defined on the basis of laboratory findings as a fasting venous plasma glucose concentration greater than 7.8mmol/l (140mg/dl) or greater than 11.1mmol/l (200mg/dl) two hours after a carbohydrate meal or two hours after an oral ingestion of the equivalent of 75g glucose, even if the fasting concentration is normal (Nwanjo, 2004).
Aim: This experiment was done to determine the synergistic antidiabetic effect of the aqueous leaf extracts of V.amygdalina and A.esculentus in alloxan induced rats
Methods: Artificial Diabetic nature was induced in rats using a diabetic inducing drug. A standard dosage of okra and bitter leaf extract was given to the rats and they were monitored for 3 weeks. Data was analyzed using SPSS Version 20. ANOVA and one sample T tests was carried out.
Results: The extracts of the two different plants worked effectively when their individual doses were increased. When combined at lower doses, (reduced blood sugar level at 3.7 mmol/l ) they tend to be more effective than in high doses (reduced blood sugar level at 3.7 mmol/l) when compared to insulin (Mixtard) at 3.56mmol/l after three weeks
Conclusion: The plant extracts had antidiabetic effects individually and when combined they were more effective at lower doses

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DOI: 
DOI: http://dx.doi.org/10.24327/ijcar.2017.5694.0780