Rphplc method development and validation for assay determination of solifenacin succinate in solifenacin succinate tablets

Ranjith Reddy., Rahul Khatal., Aniruddha V. Sherikar and Muralee Krishna

Solifenacin succinate is a competitive muscarinic acetylcholine receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle. By preventing the binding of acetylcholine to these receptors, Solifenacin reduces smooth muscle tone in the bladder, allowing the bladder to retain larger volumes of urine and reducing the number of incontinence episodes. This article describes development and validation for the assay determination of Solifenacin succinate in Solifenacin succinate Tabletsby using a high performance liquid chromatography. The high performance liquid chromatography was achieved on a Inertsil ODS 3 150 x 4.6, 5µ, column with an isocratic elution at a flow rate of 1.0mL/min.The detection was performed by a photo diode array Detector. The method was validated in the concentration range of 50% to 150% of working concentration. The intra and inter-day precision and accuracy were within Limit. The overall mean recoveries of Solifenacin succinatewere in the range of 98.0% to 102.0% for 50%, 100% and 150%.

Download PDF: 
DOI: http://dx.doi.org/10.24327/ijcar.2017.4332.0492