Role of interlukin 1 in diabetes mellitus

Bhavani G and Priyalochana Gajendran

Interleukin-1 (IL-1) family comprises of 11 cytokines, which plays central mediator of innate immunity and inflammatory response, are key regulators of multiple inflammatory diseases. Diabetes is a metabolic disease that occurs when pancreatic islets fail to produce sufficient insulin or the sensitivity of glucose metabolising tissues to insulin decreases. Diabetes is classified in to diabetes type 1 and diabetes type 2. Interleukin 1 beta has direct effect on diabetes mellitus, resulting in beta dysfunction and impaired in insulin secretion.

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