Preparation and evaluation of buccal films containing anti-hypertensive drug

Background: To prepare and evaluate of buccal films containing anti-hypertensive drug.
Material and Methods: Buccal mucoadhesive films were prepared by solvent casting method.
Results: The maximum drug release was found to be 95.20 % in formulation A3. The tensile strength of the film as the concentration of plasticizer (Propylene Glycol and Glycerin) was increased, the tensile strength of formulation was found to be decreased. The decrease in tensile strength may be due to weakening of bond linkage between the polymer chains.
Conclusion: The formulation A3 containing HPMC K4M as a film forming polymer and Propylene glycol as a plasticizer was selected as an optimized formulation because it gave higher plasticity, good in-vitro drug release and less tensile strength etc. Hence, finally it was concluded that the prepared buccal film containing Amiloride Hydrochloride is considered as a potentially useful dosage form for treatment of hypertension.