Predominance of oxidative stress in endometrial tissue as compared to systemic circulation in various subtypes of female infertility

Author: 
Ashwini Kamble., Kanchan Mohod and Satish Kumar

Background: Many studies have implicated the role of oxidative stress in female infertility. The aim of this study was to assess the effect of oxidative stress on local endometrial tissues leading to infertility in females.

Materials and methods: oxidative stress parameters like Nitric oxide and Malonaldehyde were assayed as oxidants whereas Superoxide dismutase, reduced glutathione and Vitamin E were assayed as antioxidants both in blood and in endometrial tissue of infertilitile females. Statistical analysis was performed using Z test and One Way ANOVA.

Result: Oxidants Nitric oxide and Malonaldehyde showed increase both in blood and endometrial tissue but increase was predominantly present in endometrial tissues. On the other hand antioxidants Superoxide dismutase, reduced glutathione and vitamin E showed maximum decrease in endometrial tissue as compared to blood.

Conclusion: our approach clearly indicates that oxidative stress was more pronounced at endometrial tissue level as compared to blood in females with infertility. Our study is to our knowledge become the first documented assessment in considering GSH and Vitamin E as affected antioxidants in female infertility cases especially emphasizing the direct local endometrial tissue levels.

Download PDF: