The purpose of this study is to evaluate Neuroprotective and anti- oxidant effects of Farnesol against in-vivo Parkinson’s model. Haloperidol induced Parkinson’s disease in Wistar rats was used to evaluate the neuroprotective effect of Farnesol. Haloperidol (1mg/kg) was used for the induction of disease, followed by treatment with 50 mg/kg and 100 mg/kg of farnesol for 14 days. The effect of motor symptoms was evaluated using actophotometer, rotarod apparatus and open field test. Animals showed significant improvement in locomotor activity, grip strength after the treatment of farnesol compared to disease control. Animals treated with farnesol significantly reduced Haloperidol induced alterations in the levels of neurotransmitter dopamine and anti-oxidant enzymes superoxide dismutase, catalase and lipid peroxidation. Based on the effect of farnesol on neurobehavioral and biochemical parameters in Haloperidol induced Parkinson’s, we conclude that farnesol is effective against Haloperidol induced Parkinson’s disease in Wistar rats.
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2022: 6.012
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