Nanosuspensions - a novel approach for various drug delivery systems and enhanced solubility

Nanosuspensions refer to pharmaceutical active ingredient particles that are present in a liquid phase and are dispersed in a size below 1µm. The development of new drugs is happening rapidly, resulting in a variety of promising drug candidates that work well, but do not dissolve easily in water. Nanosuspension is a possible solution to the issues that arise when working with drugs that are poorly water- and lipid-soluble because of its unique properties and submicron particle size. BCS Class II drugs have low solubility, but the use of nanotechnology increases their solubility and bioavailability. Preparing nanosuspension is a straightforward process applicable to all drugs that are insoluble in water. A nanosuspension offers a comprehensive solution to the issue of limited solubility and availability of drugs. Apart from that, its impact on pharmacokinetics paves the way for better efficacy and safety of medicines. The interaction of this technology takes place at a molecular level, making it highly specific in targeting cells and tissues, with the possibility of clinical applications yielding the most favourable therapeutic outcomes with minimal adverse effects. In this article review, the ways of preparing, characterizing and application of nanosuspensions are discussed.