Intrahepatic cholestasis of pregnancy: perinatal outcomes from a tertiary referral hospital in turkey

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Intrahepatic cholestasis of pregnancy: perinatal outcomes from a tertiary referral hospital in turkey

This retrospective cohort study included 56 women who were diagnosed with intrahepatic cholestasis of pregnancy (ICP) and 204 women in active labour who delivered in Etlik Zubeyde Hanım Women’s Health Teaching and Research Hospital between 1st January, 2013 and 31st April, 2014. There was no significant difference between the groups according to maternal age, parity or birth weight. The most common complication was oligohydramnios in both groups (12.5% vs. 7.3, p=0.3). In the study group, 10.7% newborns had meconium-stained amniotic fluid whereas 2.9% had it in the control group (p=0.02). Rates of gestational diabetes mellitus and preeclampsia were significantly higher in the ICP group (p=0.02 and p=0.02, respectively). ICP was diagnosed at 31.4±1.35 weeks of gestation (min: 28-max: 34.4). The main symptom of the patients was pruritus (98.3%). The mean total bile acids (TBA) value was 38.97±37.49 µmol/L (min: 11.2-max: 244). There was no difference in complications according to TBA values (p=0.9). The ICP rate was 0.5% in this period.

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