Insulin resistance with and without gestational diabetes meelitus an oral glucose tolerance test

Deepa R

We aimed to compare changes in insulin levels during an oral glucose tolerance test (OGTT) between women with normal glucose tolerance during pregnancy and those with gestational diabetes mellitus. Overall 60 pregnant between 25 and 28 week gestation, 30 with NGT and 30 with GDM. The level of fasting blood glucose, insulin triglyceride and total cholesterol and the insulin level , blood glucose level at 1,2 and 3 hour post oral glucose administration during an OGTT were measured. The findings suggested that insulin sensitivity in women with GDM was significantly lower than that observed in those with NGT. Reducing insulin resistance and blood lipids in women with GDM could potentially improve maternal and fetal outcomes.

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