Hba1c and microalbumin as a biomarker for early diagnosing type ii diabetes mellitus and its associated complications in the rural region of vidarbha, maharashtra, india

Sarmistha Sarkar., Ajay Meshram and Komal Meshram

Introduction: Diabetes mellitus (DM) is a group of metabolic diseases which if not controlled can cause life threatening complications.
Aim: HbA1c and Microalbumin as a Biomarker for early diagnosing Type II Diabetes Mellitus and its associated complications in the rural region of Vidarbha, Maharashtra, India.
Methodology: Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglyceride (TG), serum urea, creatinine and microalbuminuria levels were evaluated. Total sample size was 60, which was divided into 30 study group with type II DM who attended the Medicine OPD of AVBRH Hospital and 30 age matched healthy controls included in the study.
Results: Results of serum lipid profile showed higher mean of TC, TG and LDL in patients with diabetes (p<0.0001). Serum urea and creatinine levels were higher in cases as compared to the controls (p<0.0001). Urinary Microalbumin level was 70.71±5.57 which was higher in the cases as compared to controls (p<0.0001). HbA1c has significant negative correlation with HDL and Creatinine (p<0.01).
Conclusion: Early detection of lipid profile and kidney profile abnormalities can minimize the risk for development of cardiovascular and renal complications in the type II diabetic patients.

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DOI: http://dx.doi.org/10.24327/ijcar.2017.7794.1228
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