Background: Covid 19 pandemic caused by severe acute respiratory syndrome corona virus 2, mainly affects the lungs. Deranged homeostasis has been observed in patients suffering from it. Covid 19 associated coagulopathy (CAC) can cause thrombo-embolic complications in critically ill patients.
Body: The pathogenesis is likely due to endothelial injury, immobilization & an increase in circulating pro-thrombotic factors. Routine thrombo-prophylaxis with low molecular weight heparin is recommended in all patients to reduce the incidence of thrombosis.
Conclusions:
The authors present a review of the current literature available on CAC highlighting pathogenesis, clinical features & management of CAC. Systemic inflammatory response, platelet activation and endothelial dysfunction go side by side to disturb the balance between the pro and anticoagulant pathways in covid 19 disease.
Covid 19 associated coagulopathy is associated with high risk of morbidity and mortality.
This pandemic posed numerous challenges to our current medical knowledge, health care delivery and laboratory systems across the world. This review has emphasized on the various mechanisms of thrombosis, haematological aspects of the disease and anticoagulation prophylaxis in covid-19 patients.
Impact Factor
2022: 6.012
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