Genetic basis of neurological disorder with human induced pluripotent stem cells

Vigensh, M and Balachandar, V

Diseases related with the nervous system which include both central nervous system and peripheral nervous system and neurons are commonly called as neurological disease. If there are loss of neurons, mutation in the genes that code for neuron and their growth, differentiation, function and protein synthesis are also consider as a neurological problems. Today most of the aged people are affected with different neurological disease. They are Rett syndrome, Alzheimer’s disease, Parkinson’s disease, Autism Spectrum disorder, Huntington’s disease and Schizophrenia. These are the neurological disease that affected major of the population. Other diseases that are associated with neurological abnormalities are Angelman Syndrome, Trimothy syndrome and William syndrome. Today it is very complex to treat neurological patients because of several ethical and social issues. Apart from this we cannot directly use animals in the experiments for research because of multiple bioethics and bio-safety issues. In order to overcome this limitations and ethical rights, several countries are producing different models such as non - human primates, mammalian model and animal models. Thus, discoveries in stem cell technology and cell cultures leads to new direction of producing neurological models for several neurological disease and disorders. The new method in stem cell technology is called human induced Pluripotent Stem Cells (hiPSCs). Using hiPSCs several disease models are produced and we can understand the molecular mechanisms of several neurological diseases.

Download PDF: