Microspheres are free-flowing spherical particles made up of either proteins or synthetic polymers that are having sizes between 1 and 1000 μm. Microspheres are manufactured to obtain extended or controlled drug delivery to increase bioavailability and activity at the targeted site to a predetermined rate. By encouraging the production of insulin granules from the pancreatic islet beta cells, Glimepiride decreases blood sugar levels. Mucoadhesive drug delivery systems retain in the stomach for a longer period and avoid the first-pass effect. The current study's objectives are to increase gastrointestinal resident time and provide controlled oral release of Glimepiride. To achieve these goals, Glimepiride mucoadhesive microspheres were created using the ionic gelation process. The formulation of microspheres includes Glimepiride, Carbopol 934, Tragacanth, Sodium alginate, and Calcium chloride. Preformulation studies were conducted to evaluate drug excipient compatibility studies by FTIR. Formulated microspheres were evaluated for particle size, percentage yield, entrapment efficiency, swelling index, and % drug release. Among all GP3 formulation has shown the best % drug release, so selected as optimized formula. These invitro drug release results are subjected to kinetic studies of different models. It followed Peppas model indicates the mechanism of drug release i.e., release of drug from the formulation is by diffusion, erosion, swelling and may by the combination of diffusion and swelling.
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2022: 6.012
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