Ethanolic leaf extract of Jasminum grandiflorum was evaluated for hepatoprotective activity in rats. The leaf extract (100 and 200 mg/kg, p.o.) showed a remarkable hepatoprotective activity against Paracetamol induced hepatotoxicity as judged from the serum marker enzymes and antioxidant levels. In hepatoprotective study, Paracetamol induced a significant rise in Aspartate amino transferase (AST), Alanine amino transferase (ALT), Alkaline phosphatase (ALP), total bilirubin, total proteins, Lipid peroxidation (LPO), Super oxide Dismutase (SOD (100 and 200 mg/kg) significantly (P<0.001) altered serum marker enzymes and antioxidant levels to near to normal against Paracetamol treated rats. The activity of the extract at dose of 200 mg/kg was comparable to the standard drug, Silymarin (100 mg/kg, i.p.) for hepatoprotective activity. Histopathological changes of liver sample were compared with that of the respective control samples. The results indicate the hepatoprotective property of Ehanolic leaf extract of Jasminum grandiflorum exhibited a significant activity against Paracetamol induced hepatotoxicity in experimental rats.
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