Hydro-alcoholic leaf extract of Adhathoda vasica is evaluated for hepatoprotective Activity in rats. The leaf extract (50 and 100 mg/kg, p.o.) showed a remarkable Hepatoprotective activity against carbon tetrachloride (CCl4) induced hepatotoxicity as judged from the serum marker enzymes and antioxidant levels. In hepatoprotective study, carbon Tetrachloride (CCl4) induced a significant rise in Aspartate amino transferase (AST), Alanine Amino transferase (ALT), Alkaline phosphatase (ALP), Total bilirubin, Total proteins, SuperOxide Dismutase (SOD) and decrease in Lipid peroxidation (LPO). 100 mg/kg p.o. of plantExtract has significantly (P<0.001) altered serum marker enzymes and antioxidant levels to Near to normal against carbon tetrachloride (CCl4) treated rats .The activity of the extract at Dose of 100 mg/kg was comparable to the standard drug, Silymarin (100 mg/kg, p.o) for Hepatoprotective activity. Histopathological changes of liver sample were compared with that of the respective control samples. The results indicate the hepatoprotective property of Hydro-alcoholic leaf extract of Adhathoda vasica exhibited a significant activity against Carbon tetrachloride induced hepatotoxicity in experimental rats.
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