Objective: Cucumis Melo is a traditional fruit belongs to family Cucurbitaceae. The fruit peel and seeds Cucumis melo were investigated for anti-urolithiatic activity.
Method: 0.75%v/v of Ethylene glycol was administered in drinking water for inducing renal calculi and increased renal excretion of urinary calcium and oxalate for 28 days. Cucumis melo peel & seed methanolic extracts and Chloroform extracts at doses of 100mg/kg and 150mg/kg were given orally in curative and preventive regimens over a period of 28 days. Cystone (750mg/kg) was taken as standard. An increase of serum calcium, serum oxalate, BUN, creatinine, uric acid, urine volume, urine PH and histopathological studies were observed in the calculi-induced group.
Results: It was found that Cucumis melo fruit peel and seed of chloroform extracts of 100mg/kg and 150mg/kg treated the hyperoxaluria, calcium, and uric acid, and renal function was improved. Furthermore, high serum levels of urea nitrogen, creatinine and uric acid were significantly (P < 0.001) reduced by the extract.
Conclusion: The fruit Cucumis melo can be consumed by patients with kidney problems and by healthy individuals.
Impact Factor
2022: 6.012
This work is licensed under a