Effects of ethyl acetate fractions of surian leaf (toona sureni (bl.) merr.) on improvement of kidney damage caused by dehydration on male white mice

Suhatri Aini., Fita Selonni., Yufri Aldi., Puspa Pameswari and Harrizul Rivai

The effect of ethyl acetate fraction from surian leaf (Toona sureni (Bl.) Merr.) to renal impairment due to dehydration has been tested in male white mice. The mice were dehydrated by not drinking, but still fed for 3 days. The fraction of ethyl acetate from leaves surian was given orally with variation of dose 2.5 mg / kg BW, 5 mg / kg BW, and 10 mg / kg BW once daily for 7 days. Parameters observed to see improvement in renal function due to dehydration are changes in serum creatinine and renal histopathology. The results showed that the application of fraction of ethyl acetate of leaf surian showed improvement of serum creatinine level and histopathology of male white mice compared to control (p < 0.05). Provision of fraction of ethyl acetate leaf surian can improve kidney damage in group dose 10 mg / kg BW.

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DOI: http://dx.doi.org/10.24327/ijcar.2017.5653.0770