The correlation between a premature birth and the level of c-reactive protein

Introduction: A premature birth, according to the records in the literature is accompanied with releasing of many biochemical mediators in the acute phase of inflammation (transfer, ceruloplasmin, protein C-reactive). Of particular interest is to discuss the correlation of between the said mediators and premature birth.
The Aim of the Study: The aim of the study was to analyze: Correlation between the pre-matured birth and CRP level. To discuss CRP level between the mother’s blood and the fetus blood at normal and premature birth. To determine the report of CRP level in mother’s blood and the fetus blood at premature birth comparing to normal birth.
Material and Methods: In the study are included 124 pregnant patients. In pregnancy and birth giving was of normal course (77) and in a group where the pregnancy is terminated as preterm birth (47). During the act of birth giving blood samples were taken from mother’s cubic vein, from umbilical fetus vein.
The Results: Our results have shown that the level of CRP at premature birth in mother’s blood is higher (p<0.0002) in comparison to CRP level at normal term birth. At premature birth the level of CRP in fetus blood is at higher level (p<0. 001) comparing to CRP at normal term birth is explained with the fact that: due to presence of mother’s infection, uterus-placental unit and fetus the biochemical mediators are released (interleukin, endotoxins, prostate glands, human necrosis factor, prosthesis and elastases), which by acting in the liver through a serial of numerous mediators raise the CRP synthesis on one side, whereas on the other side by acting in myometrium by intermediating and releasing of mediators initiate contracting of the uterus.
Conclusion: At premature birth the level of CRP in the mother’s blood and fetal blood is at higher level compared to parameters of normal term birth. Therefore, we conclude that there is in close relation between the premature birth and CRP in mother’s and fetal blood.