Corneal endothelial evaluation in relation with diabetes mellitus

Author: 
Sunil Dattatray Zanak., Seema Zanak., Komal Zanak., Pranjali Pise and Nikhil Pise

Aim: To study relation between corneal endothelial cell density with duration and status of diabetes mellitus.
Material and Method: We randomly selected 500 cases of diabetes and 500 non diabetic patients age range from 35-70 yr. History of duration of disease and any associated diseases recorded. Endothelial cell density calculated by specular microscope. Fundus examination by indirect ophthalmoscopy after dilating pupil was done, ocular coherence tomography and fundus fluorescein angiography done when needed for assessing status of diabetic retinopathy.
Results: Mean endothelial cell density was 2056.23 in diabetics versus 2840.12 in controls. Mean endothelial cell density showed statistically significant decrease in diabetic patients. There is a negative correlation between duration of diabetes and endothelial cell density which is stastically significant. Mean endothelial cell density in diabetics with duration < 5 years were 2176.42; in 5-10 years were 1992.20, in 11-15 years: 2012.84, with 16-20 years: 2024.60 and > 20 years 1720.12. Mean endothelial cell density with no Diabetic Retinopathy was 2186.88, in diabetics with Non Proliferative Diabetic Retinopathy (NPDR) 1786.34 and with Proliferative Diabetic Retinopathy (PDR), it was 1608.96.
Conclusion: We found lower endothelial cell density with increasing severity of diabetes mellitus. Diabetes mellitus leads to decrease in endothelial cell density; affected by duration of Diabetes and severity of Diabetic retinopathy and hence needs endothelial evaluation as diabetic eye care protocol before any anterior segment intraocular surgeries.

Download PDF: 
DOI: 
DOI: http://dx.doi.org/10.24327/ijcar.2017.4084.0434
Select Volume: 
Volume6