A comparative evaluation of serum gamma glutamyl transferase and creatinine phosphokinase in diabetic and non diabetic patients with chronic periodontits

Author: 
Pavuluri Aravind Kumar., Chokkapu Sandhya Sree., S.V.V.S Musalaiah, Naga Sri.M, Indeevar.P and Ravi Raj.K

Background: Serum gamma glutamyltransferase (GGT) is an enzyme responsible
for the extracellular catabolism of glutathione could reflect several processes relevant to pathogenesis. Creatinine Kinase (CK) is expressed by various tissues which may be associated with the production and accumulation of proinflammatory cytokines in
relation to periodontal diseases.
Aim: This study is to assess the levels of serum GGT and CPK in chronic periodontitis Patients with diabetes and without diabetes before and after phase 1 therapy.
Materials and methods: A total of 20 patients with chronic periodontitis were taken and
equally divided into two groups, GroupA with diabetes and Group Bwith non diabetes. All clinical parameters like Gingival Index[GI], Plaque Index [PI], Probing Pocket Depth[PPD], Clinical Attachment Level[CAL] & biochemical parameters like serum Gamma glutamyl transferase [GGT], Creatinine phosphokinase[CPK] levels
were evaluated at baseline and three months after SRP.
Results: The present study showed a significant correlation of serum GGT and CPK in both GroupA & GroupB and these levels were elevated more in diabetic compared to non diabetic with chronic periodontitis.
Conclusion: There is a significant relation of parameters with diabetes and chronic periodontitis. The increased values of serum GGT and CPK before phase1 therapy showed a significant reduction after phase 1therapy.

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DOI: 
DOI: http://dx.doi.org/10.24327/ijcar.2017.4840.0594