Antitumor activity of methanolic extract of vernoniacinerealess by animal model

Vulli Venkata Rao

Vernoniacinerea (L.) Less a member of family compositae (Asteraceae), is an important medicinal plant has already been in used as antibacterial, Analgesic, antipyretic, anti-inflammatory preparation. In this study an attempt of the plant has been made to evaluate the anticancer activity of the methanolic extract of the plant, as stated in many hypothesis. The methanolic extract of leaves of Vernoniacinerea L. Were screened for their anticancer activity by animal model, the various parameters such as heamatological studies and protein estimation, solid tumor volume, median survival time (MST), life span (%LS). The changes in hematological parameters in mice altered significantly (p>0.01) compare to the control. There was increase the %LS (57.43), MST (36.40) and solid tumor volume was reduced significantly (p>0.01) compare to the control. Our studies point the possibility of developing Vernoniacinerea L. as a novel potential agent in the area of cancer chemotherapy. Further investigation has to be carried out in isolation and characterization of active constituents and the mechanism involving in antitumor and cytotoxic effect.

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