Oral bioavailability of poorly water-soluble drug increased by using non-ordered mesoporous silica micro particles

The aim of the study was to increase dissolution rate of Atorvastatin by the use of mesoporous silica SYLOID® 244 FP. The poorly soluble drug Atorvastatin was adsorbed on &/or into SYLOID® 244 FP in the ratio1:1, 1:1.1.5, 1:2, 1:2.5, & 1:3, 1:3.5 into a tablet by the use of wetness impregnation method. The absence of crystalline form & presence of hydrogen bond interaction between them is done by FTIR. The flowability and wettability of the atorvastatin loaded powder were evaluated by bulk & tapped density & by angle of repose, respectively. The atorvastatin loaded matrix containing lack of atorvastatin in the crystalline form & large surface area of the SYLOID® 244 FP showed improvement in the dissolution rate. Physical stability of atorvastatin & atorvastatin- SYLOID® 244 FP matrix was satisfactory observed when it is kept over a 1 month storage at 40°C and75% ± 5% humidity. Correspondingly, the solubility of Atorvastatin-loaded matrix was increased upto 2.83 times. So Atorvastatin tablet prepared from drug-loaded silica may pro¬vide a feasible approach for development of an oral formulation for this poorly water-soluble drug.