Microwave assisted synthesis, toxicological assessment using brine shrimp lethality assay and antimicrobial potential of new series of benzimidazole derivatives

A new series of benzimidazole derivatives were synthesized under microwave irradiation and structures of the synthesized compounds were confirmed by IR, NMR and Mass spectral analysis. As benzimidazole are the vital pharmacophore and privileged sub-structures in chemistry of medicine. They have received much interest in drug discovery because benzimidazoles exhibited enormous significance. So attempts have been made to create repository of molecules and evaluate them for prospective inherent activity. They are extremely effective both with respect to their inhibitory activity and favorable selectivity ratio. The present studies widen the scope of the brine shrimp model that may prove quite helpful as a preliminary screen to determine toxic properties. In Brine shrimp lethality bioassay, compounds produced dose dependent cytotoxicity effect to brine shrimp nauplii and all the synthesized compounds were screened for antibacterial activity by disc diffusion method. Among synthesized derivatives, compound code 3d showed good antibacterial activity. The benzimidazole derivatives could be considered promising broad-spectrum antimicrobial candidates that deserve further study for potential therapeutic applications.