Genetic polymorphisms of dna repair genes (xpc, xpg) and breast cancer susceptibility in maharashtrian population: a hospital based case-control study

Datkhile KD., Bhosale SJ., Patil MN., Durgawale PP and Kakade SV

Breast cancer is a major concern of women health in developing countries, including India. In this study, we aimed to find out polymorphisms in DNA repair genes, Xeroderma pigmentosum complementation group C (XPC) and XPG in patients of breast cancer from Maharashtra and to evaluate their association with breast cancer development. We conducted a case control study including 170 breast cancer cases and 200 hospital based age and sex matched healthy controls to estimate the role of genetic polymorphisms of XPC at codon 939 of the exon 15 and XPG at codon 1104 of exon 15 in the context of breast cancer risk for the Maharashtrian population. We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze gene polymorphisms. We did not find significant difference in the genotype distribution between breast cancer patients and controls for each polymorphisms studied. Thus, the case-control study suggests that the functional XPC or XPG polymorphisms could not play an important role in the development of breast cancer in a rural Maharashtrian population.

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