Antihypertensive and superoxide dismutase effect of indonesian propolis extract in kidney damage

Susanto A., Purwanto B., Mudigdo A and Suroto

Loss of redox homeostasis and formation of excessive free radicals play an important role in the pathogenesis of kidney disease and hypertension. Redox control of kidney function is a dynamic process with reversible pro– and anti-free radical processes. The imbalance of redox homeostasis within the kidney is integral in hypertension and the progression of kidney disease. Oxidative stress is associated with kidney and vascular defects leading to hypertension and atherosclerosis, being superoxide dismutase (SOD) one of the main intracellular antioxidant defence mechanisms. Ureteral obstruction may result inpermanent kidney damage. Research suggests that the Indonesian Propolis Extract (IPE) play a strong role on free oxygen radicals removal and prevents oxidative stress. This study aims to investigate the efficacy of IPE onsystolic blood pressure (SBP) levelreduction and increased levels of SOD after unilateral ureteral obstruction (UUO). A total of 32 rats were divided into four groups. Group 1 as control, Group 2 were rats with UUO, Group 3 were rats with UUO that were given IPE (oral 50 mg kg-1body weight) and Group 4 were rats with UUO that were given IPE (oral 100 mgkg-1 body weight). SBP level were measured once every week within duration of experiment and at day 30 blood sample were taken for SOD analysis. Statistical analyses was performed by one-way analysis of variance. There were statistically significant increased SBP and decreased SOD in Group 2, while there were significant decrease for SBP and increase for SOD in Group 3 and 4 (p< 0.001). In this experiment we suggest that IPE prevents kidney damage by decreasing SBP and increasing SOD.

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