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Corona virus induced disease, COVID 19 is a rapidly emerged and wide spread infection throughout the world. The disease does not have any proven medications or protocol. Therefore several medicines were trailing and hydroxychlorquine and a combination HCQ with azithromycin earned a special attention among them. The clinicians started to prescribe the patient with HCQ and combination and started reporting the clinical effects. This a small narrative review regarding the effectiveness’ of HCQ and combination in the reduction of viral load in COVID patients.