Formulation and evaluation of anti-fungal drug loaded solid lipid nanoparticles for topical delivery

Purpose: To Formulate and Evaluate Ketoconazole loaded Solid Lipid Nanoparticles and further Incorporation into Hydrogel for Sustained release.
Methods: Preparation of Ketoconazole loaded Solid Lipid Nanoparticles by Solvent emulsification/Evaporation Method.
Result: Optimized formulation of Solid Lipid Nanoparticles shown less particle size 721 nm. Hydrogel formulation showed better cumulative drug release profile after 12 hrs i.e. 82.54 %.
Conclusion: Incorporation of Solid Lipid Nanoparticles into hydrogel gave rise to biocompatible system that is able to deliver the drug in a sustained manner and effective against Candida albicans.