Retrospective Study of outcomes of Salvage Rt with ADT in patients of CA Prostate with Relapse

Background. Despite the success of Radical prostatectomy in many cases, a subset of patients experiences iochemical or structural relapse so, postoperative radiation therapy i.e., Salvage radiotherapy in combination with Androgen deprivation therapy (ADT) is one such treatment option for managing patients with Ca prostate relapse. Methodology. Survival probabilities were estimated using the Log-rank test, adjusted hazard ratios (HR) using the Cox proportional hazard regression model, genitourinary (GU) and gastrointestinal (GI) toxicities were analyzed using x2 test based on the radiation dose, and the correlation between radiation dose and quality of life was assessed. Results. The overall survival rate was 80.52% and it was found that factors such as age (p < 0.05), PSA (p < 0.05), involvement of regional lymph nodes (p < 0.05), showed statistical significance in survival rate and according to results of Cox regression, several factors like patient’s age (HR= 1.368, 95% CI: 0.666-2.810), PSA (HR= 1.986, 95% CI: 1.18-3.319), Margins (HR= 0.563, 95% CI: 0.330-0.960), EPE (HR= 0.537, 95% CI: 0.291-0.989), T-stage (HR= 1.442, 95% CI: 0.952-2.186) were statistically significant, suggesting that more than one predictor variables are related to survival. Neither of the cohorts treated with SRT experienced acute or late grade 2 GU toxicities. Only 8% of the patients had experienced grade 2 GI toxicities and the patient’s survival was also not completely associated with the total radiation dose, indicating an extremely weak and practically negligible correlation and higher ECOG status has a significant risk of mortality. Conclusion. Based on the findings it indicates that SRT along with ADT can improve survival. Thus, to increase the survival rate of patients with prostate cancer, early detection and treatment of recurrence should be implemented. Both the timing of postoperative radiotherapy and the duration of ADT have a greater impact on survival and improve both the time to salvage ADT and metastasis-free survival.