In physiological research, malocclusion is a dental condition that is frequently overlooked. It is described as any abnormality in the relationship between the dental arches, whether or not there is an aberration in the teeth developmental issue, that affects speaking, swallowing, mastication, and other processes. Although the fundamental mechanisms are unclear, mounting evidence suggests that malocclusion may be linked to dysfunction of nearby and distant organs. The framework linking malocclusion to oral (mastication, speech) and distant organ diseases, including ocular, auditory, nasal, cerebral, respiratory, musculoskeletal, cardiovascular, blood-related, renal, and sexual physiologies, still has not been united. Thus, this perspective presents a prioritised research goal to examine the causality and offers the integrated framework linking malocclusion with multiorgan pathology.
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