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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease (COVID-19), has spurred a global health crisis. To date, there are no proven options for prophylaxis for those who have been exposed to SARS-CoV-2, nor therapy for those who develop COVID-19. We provide an overview of convalescent plasma, from evidence of benefit, and proposed clinical trials, as scale up is brought underway to mobilize this critical resource.