Association between POAG and metabolic syndrome among patients attending a tertiary care centre in central India

Objectives: To evaluate the association between Primary Open-Angle Glaucoma (POAG) and Metabolic Syndrome (MetS), and to assess the prevalence of MetS components among POAG patients in a tertiary care setting in central India. Methods: A case-controlled study was conducted over 12 months at a tertiary care centre. Patients diagnosed with POAG were assessed for the presence of MetS using the modified NCEP ATP III criteria. Demographic data, clinical parameters including intraocular pressure, central corneal thickness, cup-to-disc ratio, and systemic parameters like BMI, waist circumference, fasting blood glucose, triglyceride levels, and blood pressure were recorded and analysed. Findings: Out of 200 samples, 100 cases of POAG were selected and 100 controls which is age and gender matched. A statistically significant association was found between POAG and the presence of Metabolic syndrome (p < 0.05), suggesting a possible shared pathophysiological mechanism. There was also a significant relationship between BMI and metabolic syndrome. Novelty: This study highlights a significant correlation between POAG and Metabolic syndrome in a central Indian population, suggesting the need for integrated screening approaches to improve early detection and management of both conditions.