Coronary artery disease now a days considered to be a biggest threat to the Indian population. A research study was performed to assess anger and depression among patients with coronary artery disease.Conceptual framework used for this study was based on “The Roy’s Adaptation Model”. Material and method:Non probability purposive sampling technique was adopted to select 223 coronary artery disease patients attending Cardiology OPD of selected hospitals. Tools were semi structured interview schedule on sociodemographic variables, Clinical Anger Scale for anger and Beck Depression Inventory for depression analysis. Results:The study revealed that 40.35% patients had moderate anger and 49.32% patients had moderate depression. The study also showed that depression had significant association with marital status and duration of illness of patients with coronary artery disease.