Aminofunctionalized mesoporoussilica nanoparticlesloaded with 5-fluorouracil

We report the synthesis of Amino funtionalized and Mesoporous Silica Nanoparticles and loading of 5-fluorouracil. Themesosporous silica nanoparticles (MSNs) were synthesized viaSolgel process using Cetyltrimethyl ammonium bromide (CTAB) surfactant template. The prepared nanoparticles were amino functionalized by 3-Aminopropyltriethoxysilane (APTES) toimprove drug entrapment efficiency. The drug loading of 5- fluorouracil was done by backfilling approach. The prepared amino functionalized APT-MSNs were characterized by Fourier transform Infrared (FTIR) spectroscopy. Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM) were used to study the structure and morphology of the composites.